Construction of a Vero cell line expression human KREMEN1 for the development of CVA6 vaccines
Abstract Coxsackievirus A6 (CVA6) has emerged as a major pathogen causing hand, foot and mouth disease (HFMD) outbreaks worldwide.The CVA6 epidemic poses a new challenge in HFMD control since there is currently no vaccine available against CVA6 infections.The Vero cell line has been widely used in vaccine production, particularly in the preparation